Tag Archives: PlayDNA

Dragon Duncan misses the bigger picture!

By Kelly Lea

Oxfordshire couple and co-founders of PlayDNA, Dr. Samantha Decombel and Dr. Stuart Grice, were seen on BBC2’s Dragons’ Den last night pitching for £50,000 investment in their business which creates artwork from DNA at Cherwell Innovation Centre. 

Screen shot 2014-02-03 at 12.19.00

Dr Stuart and Dr Sam face the dragons

Together for 17 years, the couple had an attractive business proposition if only the expert panel of entrepreneurs were able to keep their mind on the business in hand. Instead, viewers saw the Dragons probing for personal information about Sam and Stuart’s marital status rather than focussing on PlayDNA’s business potential, ending with Peter Jones offering the sum of £50,000 to Stuart if he proposed to Sam on the show.

group upgraded

Spot the scientists!

Undeterred by the TV experience filmed in May 2013, the business savvy couple have recently launched MuscleGenes, a sports specific spin-off company of PlayDNA, established to analyse genes that impact on fat burning, endurance, speed, metabolism and aerobic capacity.

The company already boasts celebrity clients including professional rugby player, Roger Wilson and TV presenter Andi Peters, both of whom have endorsed MuscleGenes via testimonials and social media. Celebrity doctor Dr Christian Jessen of Embarrassing Bodies fame is also known to have taken the test. Jessen

Dr. Samantha Decombel explains: “MuscleGenes has taken us to a whole new market.  Our sales have already eclipsed PlayDNA in our first few months of trading and we have experienced significant growth and appetite for our product in the UK and US.  We feel Duncan Bannatyne definitely missed a trick by not looking at the bigger picture, especially with his knowledge of the sports sector.”

The MuscleGenes test focuses solely on the information contained within an individuals DNA to help fine tune training programmes, performance and nutritional advice, with no artwork involved.

Swabbing 8-times Mr Olympia Ronnie Coleman!

Swabbing the legendary Ronnie Coleman!

The idea for MuscleGenes came about shortly after the den experience in a chance meeting with co-founder, Dr. Dan Reardon, a medic and former personal trainer.

Within 3 months MuscleGenes was formed and the impact was immediate. “Our sales went through the roof and we had to take the product off sale because we couldn’t manage the demand!” says Dr. Samantha Decombel. “In May, we were despondently walking out the den without investment. By September, we were in Vegas at the Mr Olympia event swabbing 8-times Mr Olympia Ronnie Coleman!”

MG team, Stu, Bernie, Mark, Sam, Dan

The MuscleGenes team in their lab space at Cherwell Innovation Centre

The team is already five strong with plans to recruit an additional two people to join the Cherwell Innovation Centre HQ following further investment in high-throughput equipment. Commenting on her journey to date, Dr. Samantha Decombel continues: “It is difficult for scientists to have the ability to start-up a company due to the significant investment needed in lab space and equipment.  We have been very lucky to discover Cherwell Innovation Centre, as rather than funding an entire lab, we have been able to just rent a bench in addition to sharing equipment and office space with scientists who are in a similar situation.  This has enabled us to invest in other areas, such as our branding and marketing, vital for product sales and the success of the business.”

Cherwell Innovation Centre is one of the only facilities in Oxfordshire to provide a flexible agreement for start-ups interested in lab space, office space and meeting room facilities.

MG Nation pics

The MuscleGenes Nation!
The sharp-eyed amongst you may spot a few IFBB Pros amongst the happy MG customers

MuscleGenes new website is now live with the aim of capitalising from primetime TV exposure gained through the Dragons Den appearance.  To find out more about the company and how genetics can help improve your sports performance, visit: musclegenes.com.  Alternatively, visit PlayDNA for a family DNA portrait.

IMG00693-20140202-1936

A happy ending!

For people intrigued by the Dragons’ probing into Sam and Stuart’s personal life, the University of Oxford DPhil Geneticist proposed to his business partner and girlfriend last November in Stratford-upon-Avon, the location of their first date just before Sam’s 16th birthday.  The couple are now both 33.  Dr. Samantha Decombel concludes: “We are (finally!) very happily engaged to be married and after 17 years of waiting I wouldn’t swap Stuart’s eventual proposal for any amount of Peter’s money, it was much more romantic than a TV studio!”

Leave a comment

Filed under Customer stories, Dr Samantha Decombel, Events and exhibitions, Genetics, Media, New Products, Science, Update

Doctors told us our twins were non-identical, but our DNA portraits revealed the true story

Oliver and Oscar, or is it Oscar and Oliver?

Oliver and Oscar, or is it Oscar and Oliver?

When John and Liz O’Neill were told they were going to have twins they were over the moon. During their scans they found out the twins were developing inside separate amniotic sacs, and as a result were told by the medical staff they would be non-identical.

The adorable Oscar and Oliver were born on 9th February 2012. Both parents were understandably smitten, but also amazed at how alike the tiny siblings were.

O'Neill twinsOver the next 12 months Liz and John were constantly stopped in the street or the supermarket where strangers would coo over the twins and say ‘they must be identical!’ Although they would explain no, they were actually non-identical, the twins striking similarity meant they themselves had always harboured some doubt. “I think I might have even mixed them up during bath-time once” jokes Liz.”I felt like a terrible mother because I couldn’t tell them apart!”

Shortly after the boys 1st birthday, while reading an article on twins, Liz discovered that it was actually possible for identical twins to develop in separate sacs if the egg splits very early on during development. With this new information and a sneaking suspicion that their initial instincts had always been right, Liz contacted PlayDNA to ask for help.

“I went to school with Sam, and knew through facebook that she had started a business creating DNA artwork with meaning. I thought her forensic artwork might offer some clue as to whether Ozzy and Olly were identical or not” said Liz. We agreed to help, and took samples of DNA from each family member, including the twins older brothers Jack, age 8 and Josh, age 5.

“When I saw the photos of Oliver and Oscar I too had assumed they must be identical” says Dr Sam. “I thought it would be a wonderful project to have a peek inside their genes and see what that told us about their story, and also make a wonderful family memento!”

The O'Neill family DNA Portrait

The O’Neill family DNA Portrait

Dr Sam prepared a bespoke piece of artwork for the family, which looked at ten different genes related to particular traits, such as eye colour, memory and whether you’re more likely to be an early bird or night owl. The results were pretty conclusive.

“Olly and Ozzy shared all ten genes in common – which combined with their amazing likeness is a sure sign that they are actually identical twins!” says Dr Sam. “This is made more apparent when we see their DNA portraits alongside their elder brothers, who very obviously have several differences in their DNA. We calculated the odds of them sharing these genes by coincidence, and it works out at 0.39% – in other words, less than a 1 in 200 chance. The O’Neill family now has their colourful DNA portraits framed and on the wall for all to see.

Mum Liz told us: “Thank you so much for taking the time to explain what it all means despite being so busy. We really appreciate it. It was so interesting and is all we’ve talked about since. We’ve named ourselves team night owl and are putting together our owl names and power rangers style salute! The kids are loving it. We’re so excited about having the artwork in the house and being able to explain it properly to all our family and friends. It’s a brilliant thing for the kids to be able to grow up around and learn from. I just wanted to let you know how grateful we are”.

Personalised DNA art company PlayDNA will be on Dragons’ Den on Sunday 2nd February 2014 – tune in to see how they got on!

The whole O'Neill clan!

Team Night Owl: the whole O’Neill clan!

Leave a comment

Filed under Customer stories, Dr Samantha Decombel, Genetics, Media

Komodo, the Magic Dragon

by Dr James Sleigh

To celebrate the appearance of PlayDNA on the BBC’s Dragons’ Den, we are diving into the mystical world of dragons…

Here be dragons

Here be dragons

Powerful, fearsome, venomous. A rare breed of predator with sharp claws, razor-like teeth, and an insatiable appetite. No, we are not talking about Deborah Meaden, Peter Jones, or even Duncan Bannatyne of Dragons’ Den fame. We are describing the Komodo dragon, the largest living lizard, and native of the Indonesian Islands of Southeast Asia. But, do they deserve their dragon moniker?

They have no wings, and they can’t breathe fire, you say. Nor do they live for centuries, or like to hoard gold.

A real dragon

A real dragon
Photo courtesy of http://ngm.nationalgeographic.com

Not a real dragon

Not a real dragon
Photo courtesy of http://hollywoodlife.com

Nevertheless, these creatures, which can grow to over three metres in length and eat up to 80% of their body weight in a single feed, do possess an almost mythical ability worthy of the dragon name.

0117_MALO_Komodo_Eggs_013A_t607Miraculously, in separate zoos in the UK (Chester and London), two female Komodos, which were completely isolated from males, laid clutches of eggs that resulted in lots of baby dragons. This ability for females to produce offspring without mating with a male is known as parthenogenesis, and is very rarely seen in vertebrate species (those with a backbone like you and me). In fact, only about 1 in 1,000 vertebrates can reproduce in this manner. It was particularly unexpected that such a large animal as the Komodo dragon would join this rather selective group.

Intriguingly, all the virgin baby dragons were males. This is because of the interesting genetics of Komodos. Much like we have X and Y sex chromosomes (XX = female and XY = male), Komodo dragons have W and Z chromosomes. However, rather than females having two of the same sex chromosome like humans, female Komodos have one W and one Z chromosome while males are ZZ. When female dragons are isolated from males, through parthenogenesis they are able to duplicate either their W or Z chromosome (along with the rest of their non-sex chromosomes), resulting in eggs that are either WW or ZZ. The WW eggs do not survive, but the ZZ eggs produce viable male baby dragons.

_66452824_komododragon

Hello mummy!
Photo courtesy of BBC

It is believed that this ability to switch between sexual and asexual reproduction has evolved as a strategy to be able to survive in the Komodo’s natural habitat of isolated islands. Females finding themselves washed up on unpopulated islands are able to reproduce asexually, producing males for future mating.

Fascinating.

Not quite cloning, but I’m sure some of the BBC dragons would be interested in making similar duplicates of themselves so they could make twice as much money! What’s that? You want to know the outcome of PlayDNA’s adventure in the dragon’s lair? Well, you will just have to wait until Sunday to see how Dr. Sam and Dr. Stuart fared…

PlayDNA is on Dragons Den Sunday 2nd February BBC2 at 9pm.

Leave a comment

Filed under Animals and Plants, Dr James Sleigh, Genetics, Media, Science

PlayDNA in Forbes

Forbes-MagazineWe had some particularly exciting news this week – an article on PlayDNA co-Founder Dr Samantha Decombel was published by Forbes magazine! The article, written by Lorraine Sanders, Contributing Writer for Women 2.0, documents the journey of Dr Sam from her PhD at the University of Birmingham, to part-time Lecturer in Evolutionary & Conservation Biology, all the way through to the current day, in which novel artwork genetic company PlayDNA is really taking off alongside a new spin out you’ll be hearing much more of very soon – MuscleGenes!

“It is a real honour to be recognised as a female innovator in technology by such a prestigious magazine” says Dr Sam. “The last few years have been hard work, with researching the genes we think people will enjoy learning about and developing the novel artwork to illustrate this, but we’re finally starting to see it paying off. And of course I couldn’t have got this far without such a fantastic team around me, both in PlayDNA and MuscleGenes!”

You can read the full article on Dr Sam here: The DNA of a Pivot

Leave a comment

Filed under Media

All in the genes

Dr Samantha Decombel, co-founder of PlayDNA, talks about the blossoming success of her unique DNA artwork company with Margaret Henry in this weeks Oxford Times In Business magazine.

Read the full article here: In Business article on PlayDNA

Leave a comment

Filed under Media

Come PlayDNA at Taylor Wimpey’s Kingsmere Development – and win!

The new Taylor Wimpey development at Kingsmere

The new Taylor Wimpey development at Kingsmere

Are you anywhere near Bicester in Oxfordshire this weekend? If you are, you can drop into Taylor Wimpey’s Kingsmere development and view some of our unique DNA Art on display – and as if that wasn’t enough to tempt you, you could also win a fabulous prize worth over £2000!

A keen supporter of local small businesses, home developer Taylor Wimpey have very kindly offered us the use of their three, four and five bed showroom properties for a photographic shoot. Beautifully designed inside and out, we’re looking forward to taking some stunning images!

Darren McCormack, regional sales and marketing director for Taylor Wimpey, says: “We are really pleased that we have been able to work with such a prominent local artist and help display her work. The PlayDNA artwork is totally unique and makes a great talking point for any home. What’s more, the artwork can be displayed in various different colours and formats, so you can have it styled ready to feature in your brand new home.

We love Sharmaine's traditional yet natural style. Copyright: Sharmaine Sepehr photography. Not to be reproduced without permission.

We love Sharmaine’s traditional yet natural style.
Copyright: Sharmaine Sepehr photography. Not to be reproduced without permission.

“Plus, anyone who visits the development during the event can enter into a free prize draw to win a family membership at Bicester Hotel Golf & Spa worth over £2,000!”

To make the most of this fabulous opportunity we’ve teamed up with up and coming Oxfordshire professional Wedding Photographer Sharmaine Sepehr who will be taking our shots on the day. Sharmaine specialises in family portrait photography with a creative yet unobtrusive style. She will also be providing the sample images for our new range of Framed Photo Prints. You can view a selection of Sharmaine’s work here.

A collection of our unique artwork will be on display at Taylor Wimpey’s Kingsmere development on Sunday 21st April from 10.30am to 5pm. Dr Samantha Decombel, Co-Founder of PlayDNA Ltd, will be attending personally from 11am to 1pm, so if you want to talk all things DNA, pop in and say hi!

Please click here for the full press release: DNA Artist Event at Taylor Wimpey Kingmere – Press Release

Leave a comment

Filed under Events and exhibitions, Media

Ask The Scientist: Lara’s Question

(L-R) Morgan, Lara and Brooke

(L-R) Morgan, Lara and Brooke, who set us three excellent and thought-provoking questions!

It’s time for the third and final question in our ‘Ask The Scientist’ series – a selection of questions posed by the students of Irchester Community Primary School, Northants.

Three weeks ago we tackled a really insightful question from Brooke on why DNA is in a double helix.

Our final question comes from Lara, and it’s a particularly sensitive question that many of us may have wondered at some point, but be afraid to ask for fear of causing unintended offence.

Why do people who have genetic disorders such as Down’s syndrome look similar physically?

– Lara, aged 11

down_syndrome babyIt is true that there are certain genetic disorders that it’s relatively easy to spot if a person has. Down’s syndrome is one such condition. People with Down’s syndrome tend to share a number of physical characteristics, although it’s important to recognise that not every individual with the syndrome will have them all.

These characteristics may include almond shaped eyes that slant upwards and outwards, small ears and nose and a flat nasal bridge. People with the syndrome also tend to be shorter than average with poor muscle tone and have short, broad hands with a single crease across the palm.

Down’s syndrome (also known as Down syndrome) is a genetic condition where a person inherits an extra copy (or part) of one chromosome. People with the syndrome have three copies of chromosome 21 (called a trisomy) rather than the usual two.

trisomy

Chromosomes are the structures that our DNA is stored in, and our DNA contains the genes that provide the instructions to build our bodies. It is differences in our DNA that makes us all unique, inside and out. As our DNA controls how we develop, having this extra bit of genetic material slightly alters the way Down’s syndrome babies grow in the womb of their mother, changing the finely tuned balance of the body.

The result of this is the characteristic physical features we see in Down’s syndrome. People with Down’s syndrome will also have varying degrees of learning disabilities, from mild to very severe. Around 750 babies with Down’s syndrome are born in the UK each year.  Down’s syndrome affects all ethnic groups equally, although slightly more boys are born with Down syndrome than girls.

Despite the characteristics they share in common, most importantly, like me and you, every individual with Down’s syndrome is unique. If you look past the characteristic traits we’ve described, you will see that people with Down’s syndrome, just like you and me, will inherit their looks and general characteristics from their mum and dad. Have a look at some of these family images we’ve pulled together below and you’ll see that each and every child is also a beautiful son or daughter, with all the typical family characteristics such as hair and eye colour, face and nose shape and smile.

Just like you and me, they are also all different and all unique.

x

Families with Down Syndrome v3

1 Comment

Filed under Genetics, Science, STEM

Ask the Scientist: Brooke’s Question

(L-R) Morgan, Lara and Brooke

(L-R) Morgan, Lara and Brooke, holding the helical DNA model we are all so familiar with

Our ‘Ask The Scientist’ series continues with another question from the students of Irchester Community Primary School, Northants.

Last week we tackled an excellent question from Morgan on why we all have different DNA.

This week our question comes from Brooke, and it’s another cracker!

Why is DNA in a double helix?

– Brooke, aged 10

The DNA double helix - but why?

The DNA double helix – but why?

Has it ever occurred to you why DNA is in a double helix? Nope? Me neither. It is one of those things we have always taken for granted, we don’t question it, it just IS. Which is why it sometimes takes a young and questioning mind to bring such an oversight to our attention. So we put our heads together here at PlayDNA and had a good think.

We decided there are a couple of different ways we could approach Brooke’s question.

We could look at it from a chemistry perspective and ask how, chemically, the helix is formed and what chemical or physical forces cause it to take this shape.

Or, we could look at it from a biological perspective and ask why, evolutionarily, it was this particular structure that we ended up with.

We’ll take a look at each in turn, but before we get stuck in, let’s take a moment to remind ourselves what DNA actually is.

What is DNA?

DNA is organised as two long strands of bases which twist around one another to form a double helix. DNA bases pair up with each other, A always with T and C always with G, to form units called base pairs. This is all held together by a sugar-phosphate backbone. The structure of the double helix is somewhat like a ladder, with the base pairs forming the ladder’s rungs and the sugar and phosphate molecules forming the vertical sides.

DNA is organised as two long strands of bases which twist around one another to form a double helix. DNA bases pair up with each other, A always with T and C always with G, to form units called base pairs. This is all held together by a sugar-phosphate backbone.

DNA, which stands for deoxyribonucleic acid, is the complex chemical that carries our genetic information. It is a bit like an instruction manual for building the body and keeping it healthy. We keep an entire copy of our DNA code (called our genome) in almost every cell in our body (wow!).

The information, or blueprint, for building a human being like you or me is stored in our DNA as a code made up of four chemical bases: adenine (A), guanine (G), cytosine (C) and thymine (T). These bases are joined together to form long strands, which wrap around one another to form the helix shape we are so familiar with (a bit like a twisted ladder). The human genome consists of around 3 billion pairs of these bases!

Essentially, it is the order in which these bases are organised in our DNA that tells our cells what to do.

The chemistry of the DNA double helix

The basic chemical principle behind why DNA forms a double helix is actually relatively straightforward. As we can see from the diagram above, DNA is essentially made up of three parts: sugar, phosphate and bases. It is the way in which these different molecules react to water that is key to the helical shape.

tea and sugarLet’s look at our sugar molecule first. We all know that to sweeten our tea or our fizzy pop, sugar has to dissolve in water. When something is able to dissolve in water, it is called ‘water-soluble’ or ‘hydrophilic’.

Next comes the phosphate. You might not have heard of phosphates before, but they are really very important!

Phosphate is a major nutrient required for plant growth and is a common addition to plant fertilisers (have a look at the bags of compost next time you’re at the garden centre). See what a difference it can make to how well these plants grow!

Phosphate is a major nutrient required for plant growth and is a common addition to plant fertilisers (have a look at the bags of compost next time you’re at the garden centre). See what a difference it can make to how well these plants grow!

Phosphates are involved in virtually every cellular reaction in our bodies and are key building blocks for many cellular compounds (including DNA of course!) They are absolutely essential to human, plant and animal life.

Just like the sugar, phosphates are able to easily dissolve in water too.

Finally lets consider the bases. You might have guessed by now, the bases are the opposite of the sugar and the phosphate – they hate water! They are ‘hydrophobic’ and do not dissolve in water.

Bases hate water too!

Bases hate water too!

So what happens to the bases when you put them in water? Something very similar to what happens when you mix oil and water – they pool together and don’t blend with the water at all. But most of the space in our cells is filled with water, so how do these ‘hydrophobic’ bases exist in our cells?

Well, once they are attached to a sugar and a phosphate (to form what is known as a nucleotide) they arrange themselves in such a way as to be as far away from the water as possible. Where is this? Why in the centre of the molecule of course! The water-hating bases stack themselves in the middle of the molecule while the water-loving sugar and phosphate backbone sits on the outside.

But there is another problem.

The DNA strands arrange themselves so the water-hating bases are tucked away safely in the centre of the molecule and as far away from surrounding water as possible!

The DNA strands arrange themselves so the water-hating bases are tucked away safely in the centre of the molecule and as far away from the surrounding water as possible!

If the bases just stack themselves (like a ladder) this still leaves space around the bases through which water can sneak in – and the bases don’t like that! They naturally form a position that keeps them all as far from the water as possible, just like the way oil will clump together on top of water. The most efficient position the molecule can form to do this is – you guessed it – a helix, as the ‘twist’ in the molecule closes up and minimises those gaps through the middle.

So that is why, chemically, DNA forms a double helix. It’s all simply down to the way the molecule interacts with water.

But there is another, less direct way to look at this question. A biologist (and we are all biologists here at PlayDNA!) would perhaps ask why it is this particular structure that has endured over any other type of molecule. Why has life evolved to use bases arranged in a double strand to carry our genetic code and not some other formation? Why a combination of water soluble and insoluble chemicals?

In short, why is the DNA double helix so perfect for carrying our genetic information?

The biology of the DNA double helix

As we’ve seen above, when we refer to DNA as being ‘double-stranded’, we mean that it consists of two strands of DNA bound together. However these strands are not permanently bound to one another. They can be separated for a couple of reasons:

  • So that the cell can ‘read’ the instructions contained within the DNA and tell it what to do.
  • So that the strands can be used as a template to make a whole new copy of the DNA code for a new cell – a process called ‘DNA replication.

Unbelievably, each and every one of us developed from just a single cell.

we all start out life as just a single cell complete with the original DNA copy we got from our mum and dad! As we develop, our cells duplicate, and each new cell needs its own copy of your DNA code to tell it what to do. That is a LOT of copying!

We all start out life as just a single cell complete with the original DNA copy we got from our mum & dad! As we develop, our cells duplicate, and each new cell needs its own copy of DNA to tell it what to do. That’s a LOT of copying!

x

To make new copies of your DNA code, the DNA-helix is first "unzipped". Each half will then be the template for a new, complementary strand. Biological machines inside the cell put the corresponding bases onto the split molecule and also "proof-read" the result to find and correct any mistakes. The final result is two exact copies of the original DNA molecule!

To make new copies of your DNA code, the DNA-helix is first “unzipped”. Each half will then be the template for a new, complementary strand. Biological machines inside the cell put the new bases onto the split molecule and also “proof-read” the result to correct any mistakes. The final result is two exact copies of the original DNA molecule!

From that single cell, an individual grows to around 100 trillion cells (!), and almost every one of these cells contains an entire copy our DNA (remember there are over 3 billion bases in just one copy).

That is a lot of DNA for our bodies to read and copy! It is really important then that we keep any errors in this copying to a minimum, as at this rate errors can build up quickly, and errors in our DNA code – or mutations as they are also known – are usually a bad thing.

x

In this regard, being double-stranded helps in at least two ways.

Oops, this A base appears to have been accidentally put in the new strand of DNA instead of a C base! The double stranded nature of DNA keeps these errors at very low levels, but they do still happen in our DNA all the time! Luckily most of these mutations are harmless, as they don’t occur in the important areas of our DNA.

Oops, an A base has been accidentally put in the new strand of DNA instead of a C base! The double stranded nature of DNA keeps these errors at very low levels, but they do still happen in our DNA all the time. Luckily most of these mutations are harmless, as they don’t occur in the important areas of our DNA.

Firstly, as we know, it is the chemical bases A, T, C and G that carry the DNA code. If the DNA molecule were single stranded, this important part of the molecule would be exposed to the cellular environment, which would mean a higher likelihood that it could get mutated by the numerous chemicals there. In our double stranded model however, the precious bases are kept locked away within the complex, keeping them safe from the harsh external environment.

Secondly, as we saw earlier, the two DNA strands that form the helix are essentially complementary copies of one another. An A base on one strand always pairs with a T base on the other, and likewise C always pairs with G. Having two complementary strands facing each other means that our cells always have a back up; a way to check that our DNA has been copied correctly. It allows for a level of ‘proof- reading’ of the DNA sequence so some mutations can be corrected, or at least limited.

In summary, the double-stranded DNA helix is a winning combination for packaging genetic material for the long term. It keeps our DNA code as faithful to the original as possible with its ability to be copied precisely and without errors, and offers some protection against mutation.

It is perhaps no surprise then that almost all organisms – plants, animals, yeast and bacteria – carry their genetic information encapsulated as DNA: it is the perfect molecule for the job!

s

If you have anything to add, or any more questions on this topic, please do feel free to comment below!

With thanks to Dr. Rama Balakrishnan, Stanford University (http://genetics.thetech.org/ask/ask109) and Jeremy http://medicguide.blogspot.co.uk/2008/07/why-is-dna-double-stranded-but-rna.html)

Leave a comment

Filed under Genetics, Science, STEM

Ask the Scientist: Morgan’s Question

I have always found that young people ask the most insightful of questions. They can come up with questions we would never had thought to ask, and yet, once posed, make us sit up and think “actually, yeah, why is that?”

(L-R) Morgan, Lara and Brooke

(L-R) Morgan, Lara and Brooke

Following my recent interview with the Lab_13 children of Irchester Community Primary School I was lucky enough to receive three such questions from three very bright and talented young ladies. Together with my colleagues Dr James Sleigh and Dr Stuart Grice, we have prepared responses to each of their questions in turn.

To make them a little easier to digest, I will post one a week. Our first question comes from Morgan, age 11. We hope you enjoy reading them, and feel free to add your own thoughts below!  

I know we all have different DNA but why? Why do we need to be different?

– Morgan, aged 11

Everybody does indeed have different DNA, and that is one of the things that makes you unique and who you are. However, the sequence of your DNA is almost 99.9% similar to that of another person. That means that if you were to look at the letters that make up your DNA and my DNA, 999 out of 1000 are likely to be the same. This percentage gets even higher when you compare your DNA with a relative.

If you go in the opposite direction and compare yourself with a chimpanzee, the differences become bigger and that similarity percentage goes down. I’m sure you’ve all heard of people tracing their family histories and drawing a family tree.tree of life zazzle 2 Well imagine doing that and going back a few million years. Eventually, you would come across an ancestor that you share with a chimp!

Now keep on going. If you were to go back billions of years until your tree includes every animal that ever lived, you would have drawn the “Tree of Life” and you would be able to see how life on earth has evolved, and how new species came to exist.

And this is why we all have different DNA and need to be different. For a species to be able to survive and thrive, it needs to be well adapted to its environment. Think of an African elephant with its large ears to improve heat loss and a polar bear with its extremely thick fur to keep it warm. Each species has many ‘adaptations’ in order to survive. If you were to swap the two and put an elephant in the Arctic or a polar bear in Africa, neither would live for very long!

Perfectly adapted to their environment

Perfectly adapted to their environment, but not so good in each others!

These adaptations have come about because of evolution by natural selection acting on their DNA.

playdna dna genes chromosomesIt is actually the genes in DNA that result in the different characteristics we see in all species. A gene is simply a short section of DNA that tells our cells what to do. If you think of your DNA as a recipe book, the genes are the individual recipes. Each of us has the same set of genes – about 20,000 in all. The differences between people come from slight variations in these genes.

Differences in our genes, which can come about through natural mutations in our DNA, lead to new characteristics. A lot of these changes may be bad, but some may be good, and improve the chances of an animal surviving. Those animals with genes that improve their chances of survival will be more likely to live long enough to pass on their DNA to their children than those animals that don’t possess the advantageous genes.

In recent years our environment is improving again, and with lower levels of pollution we are starting to see an upturn in lighter-coloured moth numbers- what colour are the moths near you?

In recent years our environment is improving again, and with lower levels of pollution we are starting to see an upturn in lighter-coloured moth numbers
– what colour are the moths near you?

When this selection of genes occurs over long periods of time, animals within a species can become more different from each other until two groups form that can no longer have children together. When this happens, new species have formed.

The differences in human DNA allowed our species to adapt to the environment over generations. If we go back a few thousand years, when there were no computers, or telephones, and we were living in small huts and caves, life was much harder and there was much more danger in the world. If we all had the exact same DNA, we would all be very similar in our appearance and our physical and mental abilities. That means that we would have been much more likely to die out as a species if a life-threatening change in our environment occurred, perhaps a new disease that no one was immune to for example.

Monocultures are genetically identical plant species: what do you think will happen to this crop if it was attacked by disease?

Monocultures are plantations of genetically identical plant species: what do you think will happen to this crop if it was attacked by disease?

However, having small differences in our DNA means there is a chance that some people could be immune to that disease. If attacked by a large predator like a lion, it would be those who could run faster that would survive, or maybe those who were smarter and able to hide better. These individuals would be more likely to stay alive long enough to pass on their advantageous genes.

Being different then is a good thing, not only because it means that life is a little more exciting with the diverse range of people you get to meet, but also because we are more likely to survive into the future as a species!

1 Comment

Filed under Genetics, Science, STEM

A Different Kind of Artwork

PlayDNA Lab TimesPlayDNA is in the news again – this time in the scientific press.

“Combining art and science in England’s historic heart, a few mavericks produce individual pieces of art from their customers’ DNA.

So is it art, science, or education?” In the case of PlayDNA…..it is a bit of each”.

We’re not sure we’d personally describe ourselves as ‘mavericks’ exactly (!) although we do like to think we’re making science more accessible, fun and cool!

You can read the full article here: Lab Times article

Lab Times has already established itself as one of the most popular Life Science journals in Europe and is recognised as a grassroots magazine produced by scientists for scientists.

Leave a comment

Filed under Media