PlayDNA spin-off MuscleGenes on the road to success

You can find a fantastic article on our spin out company MuscleGenes in this month’s Nutraingredients.com.

NutraIngredients.com is a daily online news service available as a free-access website and provides daily and weekly newsletters to subscribers.

The NutraIngredients.com team is led by award-winning journalists. They scan all available scientific, technical and industry sources and search out previously unpublished material, primary data and expert opinions in all areas of significance to the target audience.

You can read more about MuscleGenes here:

http://www.nutraingredients.com/Research/MuscleGenes-introduces-genetic-testing-for-fitter-future

or to visit our website please see: http://www.musclegenes.com

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Pitching for Investment: Our Journey to the Den

It all started in September 2012, when I decided to fill in the online application form for BBC2 Dragons’ Den.

Screen shot 2014-02-16 at 15.10.45Our novel DNA artwork company PlayDNA had been going commercially for about 6 months, and while we had had some successful patches following (expensive!) exhibitions in London and Oxford, with a non-existent marketing budget we were struggling to gain any momentum in terms of sales. This was not part of our original plan – we did allocate a marketing budget from the small pot of cash that was originally intended to be our first home deposit– but issues with lab work soon gobbled that up.

So what to do? How to round up that marketing budget and simultaneously generate as much interest in what we do as possible in a short time-span, at minimal cost? “Well”, I thought as I sat down at the computer, “this seemed as good a punt as any”!

I spent an hour or two filling in the application, fired it off into the abyss of the internet and waited. I heard absolutely nothing for several months, and by February 2013 had pretty much forgotten all about it. It was not a good time.

My amazing nan

My much missed, amazing nan at my PhD graduation

My seemingly indomitable and energetic nan had just passed away after a short illness and we were all feeling very down. I was back at my mum’s house the night before her funeral when I got the phone call.

It was a representative from the BBC, who wanted to have a chat about my application. I shut myself in my old bedroom and answered his questions, in what turned out to be a phone interview. At the end of it, he declared that they would be interested in seeing our pitch, and, after completing another (Pre-Audition) Questionnaire, could we come along to Television Centre at Shepherd’s Bush in London in a couple of weeks time?

“Sure” I said, before heading downstairs to explain to boyfriend and business partner Stuart what I had just got us both into! I couldn’t help thinking about what nan would have said if she were with us still, she had always supported us and I like to think she’d have been quite excited by it all.

Comic-Relief-photoshoots-2013-one-direction-33642345-541-750

Like cat-nip for girls apparently.

It was the weekend of Comic Relief 2013 when we pulled into BBC Television Centre to make our pitch to the Dragons’ Den production team. I distinctly remember the massive queue of young (and, shamefully, not so young!) girls snaking around Television Centre waiting to get a glimpse of One Direction.

It didn’t start well when I narrowly missing John Bishop’s car in my fluster getting into the poorly signposted concrete BBC carpark. After pulling ourselves together, we headed to reception (star spotting some ‘Lewis’ cast members on the way and musing on the irony of seeing them so far from our home town of Oxford) and within ten minutes or so were being shown in to the room we were to present in.

It reminded me a lot of my old school classroom: quite small, full of desks, chairs and decked out in carpet tiles. The unimposing room, and the friendliness of the production team members set us both at ease immediately. We ran through our 3-minute pitch, props and all, in front of a single camera, and managed it in a single take (it was a relief to get it all out!). We then answered a string of personal questions while the camera continued to roll, about our background and motivation for starting our own business, as well as why we wanted the money.

Sign life awayFinally, we were sat down and taken through the paperwork. There was quite a lot of it and it was all quite thorough! All done, we were thanked and shown the door, being told we would hear shortly if we were picked to go through to the final show. It was quite surreal being back out on the street afterwards. We rewarded ourselves with a burger at the Westfield Shopping Centre over the road before heading home.

Another 6 weeks passed before we heard from them again. We had once more assumed that we hadn’t made the cut, when a phone call at work one Thursday told us they had shortlisted us for the final week of filming, to start the following week. “You may, or may not get on” we were informed. Well that put us in a pickle! We were in the midst of quite a busy period, so should we take time off to prepare for something that might not happen? We decided not, and to prioritise our customer orders instead. The following day they called again. “You’re definitely on, and we’ll need you up in Manchester on Monday to prepare for filming the following day”.

Now it was time for panic stations!! It was Friday morning, we had pre-arranged plans for the weekend and we were expected to be ready to pitch to the dragons next Tuesday. Oh, and did I mention the reams of paperwork we were sent through to complete?tons-of-paperwork An 18-point list of information we would need to provide them with beforehand, from outline business plan, to evidence of domain ownership, legal approvals, insurances, market research on competitors, evidence of sales, it went on and on! It took me until Sunday afternoon to complete the paperwork. Meanwhile Stuart worked on the improved pitch, and pulling all our figures together. If there was one thing we were certain of it was that we weren’t going to be caught out on the figures or valuation.

We know how to argue like cat and dog

We know how to argue like cat and dog

We drove up to Manchester on Monday late afternoon. The BBC had arranged for us to stay in a hotel the night before, as we were being picked up early the next day. We were getting quite stressed by this time and starting to bicker over the detail – at one point during our journey Stuart threatened to jump out of the car while we were on the motorway!

Suffice to say after 17 years together we’ve had enough big bust ups to know when we’re over-reacting and made up shortly afterwards.

We ran through our pitch for the first time that evening – it wasn’t the only pitch we had our minds on that night though.

Like Villa's motto - we did our best to 'Be Prepared' (after the match of course)

Like Villa’s motto – we did our best to ‘Be Prepared’ (after the match of course)

Memorising the figures was made all that much harder by there being a rather exciting Villa game on in the background. Villa demolished Sunderland 6-1 in a vital relegation battle match, so we consoled ourselves that the week couldn’t be all bad!

The morning came. It was Tuesday 30th April when we were to finally get in front of the dragons. The car came at 7am to pick us up and whisk us to the studio at Media City, Manchester…

Find out more about our ‘day in the den’ this time next week!

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Dragon Duncan misses the bigger picture!

By Kelly Lea

Oxfordshire couple and co-founders of PlayDNA, Dr. Samantha Decombel and Dr. Stuart Grice, were seen on BBC2’s Dragons’ Den last night pitching for £50,000 investment in their business which creates artwork from DNA at Cherwell Innovation Centre. 

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Dr Stuart and Dr Sam face the dragons

Together for 17 years, the couple had an attractive business proposition if only the expert panel of entrepreneurs were able to keep their mind on the business in hand. Instead, viewers saw the Dragons probing for personal information about Sam and Stuart’s marital status rather than focussing on PlayDNA’s business potential, ending with Peter Jones offering the sum of £50,000 to Stuart if he proposed to Sam on the show.

group upgraded

Spot the scientists!

Undeterred by the TV experience filmed in May 2013, the business savvy couple have recently launched MuscleGenes, a sports specific spin-off company of PlayDNA, established to analyse genes that impact on fat burning, endurance, speed, metabolism and aerobic capacity.

The company already boasts celebrity clients including professional rugby player, Roger Wilson and TV presenter Andi Peters, both of whom have endorsed MuscleGenes via testimonials and social media. Celebrity doctor Dr Christian Jessen of Embarrassing Bodies fame is also known to have taken the test. Jessen

Dr. Samantha Decombel explains: “MuscleGenes has taken us to a whole new market.  Our sales have already eclipsed PlayDNA in our first few months of trading and we have experienced significant growth and appetite for our product in the UK and US.  We feel Duncan Bannatyne definitely missed a trick by not looking at the bigger picture, especially with his knowledge of the sports sector.”

The MuscleGenes test focuses solely on the information contained within an individuals DNA to help fine tune training programmes, performance and nutritional advice, with no artwork involved.

Swabbing 8-times Mr Olympia Ronnie Coleman!

Swabbing the legendary Ronnie Coleman!

The idea for MuscleGenes came about shortly after the den experience in a chance meeting with co-founder, Dr. Dan Reardon, a medic and former personal trainer.

Within 3 months MuscleGenes was formed and the impact was immediate. “Our sales went through the roof and we had to take the product off sale because we couldn’t manage the demand!” says Dr. Samantha Decombel. “In May, we were despondently walking out the den without investment. By September, we were in Vegas at the Mr Olympia event swabbing 8-times Mr Olympia Ronnie Coleman!”

MG team, Stu, Bernie, Mark, Sam, Dan

The MuscleGenes team in their lab space at Cherwell Innovation Centre

The team is already five strong with plans to recruit an additional two people to join the Cherwell Innovation Centre HQ following further investment in high-throughput equipment. Commenting on her journey to date, Dr. Samantha Decombel continues: “It is difficult for scientists to have the ability to start-up a company due to the significant investment needed in lab space and equipment.  We have been very lucky to discover Cherwell Innovation Centre, as rather than funding an entire lab, we have been able to just rent a bench in addition to sharing equipment and office space with scientists who are in a similar situation.  This has enabled us to invest in other areas, such as our branding and marketing, vital for product sales and the success of the business.”

Cherwell Innovation Centre is one of the only facilities in Oxfordshire to provide a flexible agreement for start-ups interested in lab space, office space and meeting room facilities.

MG Nation pics

The MuscleGenes Nation!
The sharp-eyed amongst you may spot a few IFBB Pros amongst the happy MG customers

MuscleGenes new website is now live with the aim of capitalising from primetime TV exposure gained through the Dragons Den appearance.  To find out more about the company and how genetics can help improve your sports performance, visit: musclegenes.com.  Alternatively, visit PlayDNA for a family DNA portrait.

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A happy ending!

For people intrigued by the Dragons’ probing into Sam and Stuart’s personal life, the University of Oxford DPhil Geneticist proposed to his business partner and girlfriend last November in Stratford-upon-Avon, the location of their first date just before Sam’s 16th birthday.  The couple are now both 33.  Dr. Samantha Decombel concludes: “We are (finally!) very happily engaged to be married and after 17 years of waiting I wouldn’t swap Stuart’s eventual proposal for any amount of Peter’s money, it was much more romantic than a TV studio!”

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Doctors told us our twins were non-identical, but our DNA portraits revealed the true story

Oliver and Oscar, or is it Oscar and Oliver?

Oliver and Oscar, or is it Oscar and Oliver?

When John and Liz O’Neill were told they were going to have twins they were over the moon. During their scans they found out the twins were developing inside separate amniotic sacs, and as a result were told by the medical staff they would be non-identical.

The adorable Oscar and Oliver were born on 9th February 2012. Both parents were understandably smitten, but also amazed at how alike the tiny siblings were.

O'Neill twinsOver the next 12 months Liz and John were constantly stopped in the street or the supermarket where strangers would coo over the twins and say ‘they must be identical!’ Although they would explain no, they were actually non-identical, the twins striking similarity meant they themselves had always harboured some doubt. “I think I might have even mixed them up during bath-time once” jokes Liz.”I felt like a terrible mother because I couldn’t tell them apart!”

Shortly after the boys 1st birthday, while reading an article on twins, Liz discovered that it was actually possible for identical twins to develop in separate sacs if the egg splits very early on during development. With this new information and a sneaking suspicion that their initial instincts had always been right, Liz contacted PlayDNA to ask for help.

“I went to school with Sam, and knew through facebook that she had started a business creating DNA artwork with meaning. I thought her forensic artwork might offer some clue as to whether Ozzy and Olly were identical or not” said Liz. We agreed to help, and took samples of DNA from each family member, including the twins older brothers Jack, age 8 and Josh, age 5.

“When I saw the photos of Oliver and Oscar I too had assumed they must be identical” says Dr Sam. “I thought it would be a wonderful project to have a peek inside their genes and see what that told us about their story, and also make a wonderful family memento!”

The O'Neill family DNA Portrait

The O’Neill family DNA Portrait

Dr Sam prepared a bespoke piece of artwork for the family, which looked at ten different genes related to particular traits, such as eye colour, memory and whether you’re more likely to be an early bird or night owl. The results were pretty conclusive.

“Olly and Ozzy shared all ten genes in common – which combined with their amazing likeness is a sure sign that they are actually identical twins!” says Dr Sam. “This is made more apparent when we see their DNA portraits alongside their elder brothers, who very obviously have several differences in their DNA. We calculated the odds of them sharing these genes by coincidence, and it works out at 0.39% – in other words, less than a 1 in 200 chance. The O’Neill family now has their colourful DNA portraits framed and on the wall for all to see.

Mum Liz told us: “Thank you so much for taking the time to explain what it all means despite being so busy. We really appreciate it. It was so interesting and is all we’ve talked about since. We’ve named ourselves team night owl and are putting together our owl names and power rangers style salute! The kids are loving it. We’re so excited about having the artwork in the house and being able to explain it properly to all our family and friends. It’s a brilliant thing for the kids to be able to grow up around and learn from. I just wanted to let you know how grateful we are”.

Personalised DNA art company PlayDNA will be on Dragons’ Den on Sunday 2nd February 2014 – tune in to see how they got on!

The whole O'Neill clan!

Team Night Owl: the whole O’Neill clan!

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Komodo, the Magic Dragon

by Dr James Sleigh

To celebrate the appearance of PlayDNA on the BBC’s Dragons’ Den, we are diving into the mystical world of dragons…

Here be dragons

Here be dragons

Powerful, fearsome, venomous. A rare breed of predator with sharp claws, razor-like teeth, and an insatiable appetite. No, we are not talking about Deborah Meaden, Peter Jones, or even Duncan Bannatyne of Dragons’ Den fame. We are describing the Komodo dragon, the largest living lizard, and native of the Indonesian Islands of Southeast Asia. But, do they deserve their dragon moniker?

They have no wings, and they can’t breathe fire, you say. Nor do they live for centuries, or like to hoard gold.

A real dragon

A real dragon
Photo courtesy of http://ngm.nationalgeographic.com

Not a real dragon

Not a real dragon
Photo courtesy of http://hollywoodlife.com

Nevertheless, these creatures, which can grow to over three metres in length and eat up to 80% of their body weight in a single feed, do possess an almost mythical ability worthy of the dragon name.

0117_MALO_Komodo_Eggs_013A_t607Miraculously, in separate zoos in the UK (Chester and London), two female Komodos, which were completely isolated from males, laid clutches of eggs that resulted in lots of baby dragons. This ability for females to produce offspring without mating with a male is known as parthenogenesis, and is very rarely seen in vertebrate species (those with a backbone like you and me). In fact, only about 1 in 1,000 vertebrates can reproduce in this manner. It was particularly unexpected that such a large animal as the Komodo dragon would join this rather selective group.

Intriguingly, all the virgin baby dragons were males. This is because of the interesting genetics of Komodos. Much like we have X and Y sex chromosomes (XX = female and XY = male), Komodo dragons have W and Z chromosomes. However, rather than females having two of the same sex chromosome like humans, female Komodos have one W and one Z chromosome while males are ZZ. When female dragons are isolated from males, through parthenogenesis they are able to duplicate either their W or Z chromosome (along with the rest of their non-sex chromosomes), resulting in eggs that are either WW or ZZ. The WW eggs do not survive, but the ZZ eggs produce viable male baby dragons.

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Hello mummy!
Photo courtesy of BBC

It is believed that this ability to switch between sexual and asexual reproduction has evolved as a strategy to be able to survive in the Komodo’s natural habitat of isolated islands. Females finding themselves washed up on unpopulated islands are able to reproduce asexually, producing males for future mating.

Fascinating.

Not quite cloning, but I’m sure some of the BBC dragons would be interested in making similar duplicates of themselves so they could make twice as much money! What’s that? You want to know the outcome of PlayDNA’s adventure in the dragon’s lair? Well, you will just have to wait until Sunday to see how Dr. Sam and Dr. Stuart fared…

PlayDNA is on Dragons Den Sunday 2nd February BBC2 at 9pm.

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Happiness is in the genes of the beholder

It’s a grey miserable Friday the 13th, so what better time to think about happiness! james2 copy

 
The always cheerful (no matter what the weather!) Dr James Sleigh explains how recent research suggests that happiness and health are actually linked on a biological level…
 

How often do you feel happy?

 
How often do you feel that you have contributed something to society? How often do you feel that you belong to a community group?
 

CharlotteWell, the answers to those questions now appear to affect more than just your mental and social well-being. New research suggests that your level of long-term happiness and self-satisfaction also has a significant effect on your genes.

A team of scientists in the US decided to study how positive psychology impacts gene expression levels in humans.

centraldogma copyGenes are short sections of your DNA that are copied to produce intermediate molecules called RNA, which can then be used as templates to create proteins, the fundamental components of all cells. When we talk about gene expression levels, we are describing how many intermediate ‘RNA’ copies are made from a particular gene.

When a gene or sets of genes are expressed at different levels to what is expected or normally observed in a particular group of people, this can sometimes indicate that something is perhaps not quite right.

Jo and familyv1In the study, the researchers took blood samples from 80 healthy people and looked at the expression of all the genes in the human body.

They also asked the volunteers a range of questions about their psychological well-being in order to determine whether their happiness was more due to having a deep sense of purpose in life, or perhaps more due to instant self-gratification, for example through going on regular holidays or getting to eat your favourite food.

sam and stuThe study found that those people who believed that they had a greater meaning in life had low expression of genes involved in unwanted inflammation and high expression of genes linked to a healthy immune system.

The opposite was true of the group of people whose happiness was mainly a product of immediate self-satisfaction.

These differences can have a major impact on general health because having high expression of inflammatory genes is linked to cardiovascular and other diseases, while having low expression of immune system genes can affect your ability to fight off infection.

Kel and Scotty

Interestingly, both groups had similar positive feelings about their lives, indicating that the subtle differences in happiness have a greater effect on the genome, and therefore your health, than they do on the conscious adult mind.

So the moral of the story is that doing good by others and trying to live a meaningful life is perhaps better for your long-term health than making yourself feel happy in the short term.

Reference: A functional genomic perspective on human well-being (2013) PNAS
http://www.pnas.org/content/early/2013/07/25/1305419110.abstract?sid=df96ab02-ac3b-4d8b-89e1-1e041a7a3c14

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PlayDNA in Forbes

Forbes-MagazineWe had some particularly exciting news this week – an article on PlayDNA co-Founder Dr Samantha Decombel was published by Forbes magazine! The article, written by Lorraine Sanders, Contributing Writer for Women 2.0, documents the journey of Dr Sam from her PhD at the University of Birmingham, to part-time Lecturer in Evolutionary & Conservation Biology, all the way through to the current day, in which novel artwork genetic company PlayDNA is really taking off alongside a new spin out you’ll be hearing much more of very soon – MuscleGenes!

“It is a real honour to be recognised as a female innovator in technology by such a prestigious magazine” says Dr Sam. “The last few years have been hard work, with researching the genes we think people will enjoy learning about and developing the novel artwork to illustrate this, but we’re finally starting to see it paying off. And of course I couldn’t have got this far without such a fantastic team around me, both in PlayDNA and MuscleGenes!”

You can read the full article on Dr Sam here: The DNA of a Pivot

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All in the genes

Dr Samantha Decombel, co-founder of PlayDNA, talks about the blossoming success of her unique DNA artwork company with Margaret Henry in this weeks Oxford Times In Business magazine.

Read the full article here: In Business article on PlayDNA

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Come PlayDNA at Taylor Wimpey’s Kingsmere Development – and win!

The new Taylor Wimpey development at Kingsmere

The new Taylor Wimpey development at Kingsmere

Are you anywhere near Bicester in Oxfordshire this weekend? If you are, you can drop into Taylor Wimpey’s Kingsmere development and view some of our unique DNA Art on display – and as if that wasn’t enough to tempt you, you could also win a fabulous prize worth over £2000!

A keen supporter of local small businesses, home developer Taylor Wimpey have very kindly offered us the use of their three, four and five bed showroom properties for a photographic shoot. Beautifully designed inside and out, we’re looking forward to taking some stunning images!

Darren McCormack, regional sales and marketing director for Taylor Wimpey, says: “We are really pleased that we have been able to work with such a prominent local artist and help display her work. The PlayDNA artwork is totally unique and makes a great talking point for any home. What’s more, the artwork can be displayed in various different colours and formats, so you can have it styled ready to feature in your brand new home.

We love Sharmaine's traditional yet natural style. Copyright: Sharmaine Sepehr photography. Not to be reproduced without permission.

We love Sharmaine’s traditional yet natural style.
Copyright: Sharmaine Sepehr photography. Not to be reproduced without permission.

“Plus, anyone who visits the development during the event can enter into a free prize draw to win a family membership at Bicester Hotel Golf & Spa worth over £2,000!”

To make the most of this fabulous opportunity we’ve teamed up with up and coming Oxfordshire professional Wedding Photographer Sharmaine Sepehr who will be taking our shots on the day. Sharmaine specialises in family portrait photography with a creative yet unobtrusive style. She will also be providing the sample images for our new range of Framed Photo Prints. You can view a selection of Sharmaine’s work here.

A collection of our unique artwork will be on display at Taylor Wimpey’s Kingsmere development on Sunday 21st April from 10.30am to 5pm. Dr Samantha Decombel, Co-Founder of PlayDNA Ltd, will be attending personally from 11am to 1pm, so if you want to talk all things DNA, pop in and say hi!

Please click here for the full press release: DNA Artist Event at Taylor Wimpey Kingmere – Press Release

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Ask The Scientist: Lara’s Question

(L-R) Morgan, Lara and Brooke

(L-R) Morgan, Lara and Brooke, who set us three excellent and thought-provoking questions!

It’s time for the third and final question in our ‘Ask The Scientist’ series – a selection of questions posed by the students of Irchester Community Primary School, Northants.

Three weeks ago we tackled a really insightful question from Brooke on why DNA is in a double helix.

Our final question comes from Lara, and it’s a particularly sensitive question that many of us may have wondered at some point, but be afraid to ask for fear of causing unintended offence.

Why do people who have genetic disorders such as Down’s syndrome look similar physically?

– Lara, aged 11

down_syndrome babyIt is true that there are certain genetic disorders that it’s relatively easy to spot if a person has. Down’s syndrome is one such condition. People with Down’s syndrome tend to share a number of physical characteristics, although it’s important to recognise that not every individual with the syndrome will have them all.

These characteristics may include almond shaped eyes that slant upwards and outwards, small ears and nose and a flat nasal bridge. People with the syndrome also tend to be shorter than average with poor muscle tone and have short, broad hands with a single crease across the palm.

Down’s syndrome (also known as Down syndrome) is a genetic condition where a person inherits an extra copy (or part) of one chromosome. People with the syndrome have three copies of chromosome 21 (called a trisomy) rather than the usual two.

trisomy

Chromosomes are the structures that our DNA is stored in, and our DNA contains the genes that provide the instructions to build our bodies. It is differences in our DNA that makes us all unique, inside and out. As our DNA controls how we develop, having this extra bit of genetic material slightly alters the way Down’s syndrome babies grow in the womb of their mother, changing the finely tuned balance of the body.

The result of this is the characteristic physical features we see in Down’s syndrome. People with Down’s syndrome will also have varying degrees of learning disabilities, from mild to very severe. Around 750 babies with Down’s syndrome are born in the UK each year.  Down’s syndrome affects all ethnic groups equally, although slightly more boys are born with Down syndrome than girls.

Despite the characteristics they share in common, most importantly, like me and you, every individual with Down’s syndrome is unique. If you look past the characteristic traits we’ve described, you will see that people with Down’s syndrome, just like you and me, will inherit their looks and general characteristics from their mum and dad. Have a look at some of these family images we’ve pulled together below and you’ll see that each and every child is also a beautiful son or daughter, with all the typical family characteristics such as hair and eye colour, face and nose shape and smile.

Just like you and me, they are also all different and all unique.

x

Families with Down Syndrome v3

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